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Bioinspired Core–Shell Nanoparticles for Hydrophobic Drug Delivery

GDCH. 2019-07; 
Guangze Yang, Yun Liu, Haofei Wang, Russell Wilson, Yue Hui, Lei Yu, David Wibowo, Cheng Zhang, Andrew K. Whittaker, Anton P. J. Middelberg, and Chun-Xia Zhao
Products/Services Used Details Operation
Peptide Synthesis Peptides SurSi (3632.37 g mol-1 ) and CAMSi (4555.48 g mol-1 ) were custom synthesized by GenScript Corporation (Piscataway, NJ). Get A Quote

摘要

A large range of nanoparticles have been developed to encapsulate hydrophobic drugs. However, drug loading is usually less than 10% or even 1%. Now, core–shell nanoparticles are fabricated having exceptionally high drug loading up to 65% (drug weight/the total weight of drug-loaded nanoparticles) and high encapsulation efficiencies (> 99%) based on modular biomolecule templating. Bifunctional amphiphilic peptides are designed to not only stabilize hydrophobic drug nanoparticles but also induce biosilicification at the nanodrug particle surface thus forming drug-core silica– shell nanocomposites. This platform technology is highly versatile for encapsulating various hydrophobic cargos. Furthermore, t... More

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