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LR3-IGF-I (Media Grade), Human

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Human LR3 Insulin-like Growth Factor-I (LR3-IGF-I) is an 83 amino acid analog of human IGF-I comprising the complete human IGF-I sequence with the substitution of an Arg for the Glu at position 3 (hence R3), and a 13 amino acid extension peptide at the N-terminus. Scientists have engineered this analog with the express purpose of increasing biological activity. Human LR3-IGF-I is significantly more potent than human IGF-I in vitro. The enhanced potency is due to the markedly decreased binding of human LR3-IGF-I to IGF binding proteins which normally inhibit the biological actions of IGFs.GenScript LR3 Insulin-like Growth Factor-I (LR3-IGF-I) (Media Grade), human, produced in E. coli, is a single, non-glycosylated, polypeptide chain containing 83 amino acids and having a molecular mass of 9,111 Da.
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Species Human
Purity >98 % by SDS-PAGE analyses.90 % by RP-HPLC analyses
Endotoxin Level The endotoxin level of GenScript Recombinant Human LR3-IGF-I is below 0.1 ng/μg (1 IEU/μg) of LR3-IGF-I.
Formulation Lyophilized from a 0.2 μm filtered concentrated solution in 20 mM PB, pH 7.2.
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1 % BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 °C. Further dilutions should be made in appropriate buffered solutions.

Target Background Human LR3 Insulin-like Growth Factor-I (LR3-IGF-I) is an 83 amino acid analog of human IGF-I comprising the complete human IGF-I sequence with the substitution of an Arg for the Glu at position 3 (hence R3), and a 13 amino acid extension peptide at the N-terminus. Scientists have engineered this analog with the express purpose of increasing biological activity. Human LR3-IGF-I is significantly more potent than human IGF-I in vitro. The enhanced potency is due to the markedly decreased binding of human LR3-IGF-I to IGF binding proteins which normally inhibit the biological actions of IGFs.
GenScript LR3 Insulin-like Growth Factor-I (LR3-IGF-I) (Media Grade), human, produced in E. coli, is a single, non-glycosylated, polypeptide chain containing 83 amino acids and having a molecular mass of 9,111 Da.
Synonyms LR3 Insulin-like Growth Factor-I (LR3-IGF-I) (Media Grade), human; LR3-IGF-I;

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