InsB 9-23

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This insulin B-chain peptide binds to a class II histocompatibility complex (MHC) allele called I-Ag7. A number of autoimmune diseases has been linked to class II proteins encoded by the MHC. Type 1 diabetes, or insulin-dependent diabetes mellitus, is a T cell-mediated disease that results in autoimmune destruction of pancreatic ß cells leading to hyperglycemia. This insulin B peptide may be a self-antigen candidate that could initiate the disease. Immunization with this peptide in mice led to autoantibodies and insulitis.

产品编号	RP20391
规格	定制报价

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产品概述

Description	This insulin B-chain peptide binds to a class II histocompatibility complex (MHC) allele called I-Ag7. A number of autoimmune diseases has been linked to class II proteins encoded by the MHC. Type 1 diabetes, or insulin-dependent diabetes mellitus, is a T cell-mediated disease that results in autoimmune destruction of pancreatic ß cells leading to hyperglycemia. This insulin B peptide may be a self-antigen candidate that could initiate the disease. Immunization with this peptide in mice led to autoantibodies and insulitis.
Sequence	{Ser}{His}{Leu}{Val}{Glu}{Ala}{Leu}{Tyr}{Leu}{Val}{Cys}{Gly} {Glu}{Arg}{Gly}
Sequence Shortening	SHLVEALYLVCGERG
Molecular Formula	C₇₂H₁₁₆N₂₀O₂₂S₁
Molecular Weight	1645.9