目录产品 » Apamin

Apamin

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Apamin, a bee venom polypeptide, blocks specifically the Ca2+-dependent K+ channels that are not blocked by tetraethylammonium chloride in muscle cells. Apamin is a highly specific compound that tightly binds to the Ca2+ slow channels, thus blocking the slow APs in heart muscle. In addition, quinidine antagonizes the apamin binding on the slow APs.
RP11002
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产品概述
Description Apamin, a bee venom polypeptide, blocks specifically the Ca2+-dependent K+ channels that are not blocked by tetraethylammonium chloride in muscle cells. Apamin is a highly specific compound that tightly binds to the Ca2+ slow channels, thus blocking the slow APs in heart muscle. In addition, quinidine antagonizes the apamin binding on the slow APs.
Cas No 24345-16-2
Sequence
{CYS}{ASN}{CYS}{LYS}{ALA}{PRO}{GLU}{THR}{ALA}{LEU}{CYS}{ALA}{ARG}{ARG}{CYS}{GLN}{GLN}{HIS}-NH2
Sequence Shortening CNCKAPETALCARRCQQH-NH2
Molecular Formula C79H131N31O24S4
C Terminal NH2
Disulfide Bridge Cys1-Cys11, Cys3-Cys15
Molecular Weight 2027.3

产品属性
Purity > 95%
Form Lyophilized
Storage Store at -20°C. Keep tightly closed. Store in a cool dry place.
Note Originally isolated from Apis mellifera. A small conductance Ca2+-activated K+ channel blocker.

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