Endomorphin-2
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Endomorphin 2 is a potent, selective endogenous µ opioid receptor agonist. The physiological function of endomorphin-2 as a neurotransmitter or neuromodulator may cease through the rapid enzymatic process in the synapse of brain, as for other neuropeptides. Some results indicate that the administration of the endogenous µ-opioid ligand endomorphin-2, but not endomorphin-1, into the brain produces an antitussive effect via mainly naloxonazine-insensitive µ-opioid receptors, namely µ2-opioid receptors and partially kappa-opioid receptors.
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