Syntide 2
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The native peptide PLARTLSVAGLPGKK is a selective substrate for CaM kinase II and PKC. It is also a poor substrate for phosphorylase kinase and is not phosphorylated by myosin light chain kinase. The sequence of PLARTLSVAGLPGKK is homologous to phosphorylation site 2 in glycogen synthase. The relative Vmax/Km ratios of the peptide for different kinases are 100 for CaMK II, 22 for PKC, 2 for phosphorylase kinase, and 0.5 for myosin light chain kinase, respectively.
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