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Substance P (1-9)

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Subtance P is responsible for a number of excitatory effects on both central and peripheral neurons. Substance P contracts smooth muscle, constricts bronchioles and increases capillary permeability. When released from afferent nerves, Substance P causes a neurogenic inflammatory response, including mast cell degranulation. NK-1 agonist; potent vasodilator and hypotensive agent; induces salivation; putative neurotransmitter in sensory (pain) afferents. Substance P(1-9) is a fragment of Subtance P. Accumulating evidence shows that N- and C-terminal substance P fragments have significant biological activity. Substance P(1-9) has been reported to be major substance P metabolites in rat striatum and it has modulatory effects similar to substance P.
RP10181
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Cas No 57468-17-4
Sequence
{ARG}{PRO}{LYS}{PRO}{GLN}{GLN}{PHE}{PHE}{GLY}
Sequence Shortening RPKPQQFFG
Molecular Formula C52H77N15O12
Molecular Weight 1104.3

Purity > 95%
Storage Store at -20°C。

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