Human PLA2R1 Antibody (6E8), mAb, Mouse

PLA2R1 (Phospholipase A2 Receptor 1) is a protein coding gene. The encoded protein likely exists as both a transmembrane form and a soluble form. The transmembrane receptor may play a role in clearance of phospholipase A2, thereby inhibiting its action. The soluble secretory phospholipase A2 receptor form is circulating and acts as a negative regulator of sPLA2 (secretory phospholipase A2) functions by blocking the biological functions of sPLA2-IB/PLA2G1B. Diseases associated with PLA2R1 include Membranoproliferative Glomerulonephritis and Membranous Nephropathy. Among its related pathways are metabolism and acyl chain remodeling of PE (phosphatidylethanolamine). Alternatively spliced transcript variants encoding different isoforms have been identified.