| Specificity |
The product is specific for human GLP1R. |
| Host Species |
Mouse |
| Immunogen |
a plasmid DNA encoding a full length of human GLP1R (Swiss prot: P43220) |
| Species Reactivity |
human |
| Conjugate |
Unconjugated |
|
Working concentrations for specific applications should be determined by the investigator. The appropriate concentration may be affected by secondary antibody affinity, antigen concentration, the sensitivity of the method of detection, temperature, the length of the incubations, and other factors. The suitability of this antibody for applications other than those listed below has not been determined. The following concentration ranges are recommended starting points for this product. |
| Application |
Recommended Usage |
| Immunocytochemistry/Immunofluorescence (ICC/IF) |
4 µg/ml |
| Flow Cytometry |
1-5 µg/ml |
| ELISA |
0.1 µg/ml |
|
| Form |
Lyophilized |
| Storage Buffer |
lyophilized with PBS, pH 7.4, containing 0.02% sodium azide |
| Reconstitution |
Reconstitute the lyophilized powder with deionized water (or equivalent) to an final concentration of 0.5 mg/mL. |
| Storage Instructions |
The lyophilized product remains stable up to 1 years at -20 °C from date of receipt. Upon reconstitution, it can be stored for 2-3 weeks at 2-8 °C or for up to 12 months at -20 °C or below. Avoid repeated freezing and thawing cycles. |
| Purification |
Protein A affinity column |
| Isotype |
Mouse IgG1,κ |
| Clonality |
Monoclonal |
| Clone ID |
1F1E7 |
| Note |
GenScript can customize this product per customer's request including product size, buffer components, etc. |
| Target Background |
GLP1R binds specifically the glucagon-like peptide-1 (GLP1) and has much lower affinity for related peptides such as the gastric inhibitory polypeptide and glucagon. GLP1R is known to be expressed in pancreatic beta cells. Activated GLP1R stimulates the adenylyl cyclase pathway which results in increased insulin synthesis and release of insulin. Consequently, GLP1R has been suggested as a potential target for the treatment of diabetes. GLP1R is also expressed in the brain where it is involved in the control of appetite. Furthermore, mice which over express GLP1R display improved memory and learning.GenScript GLP1R Antibody, mAb, Mouse is produced from a hybridoma resulting from fusion of SP2/0-Ag14 myeloma and B-lymphocytes obtained from a mouse immunized with a plasmid DNA encoding a full length of human GLP1R (Swiss prot: P43220). |
| Synonyms |
GLP1R Antibody, mAb, Mouse |
For laboratory research use only. Direct human use, including taking orally and injection and clinical use are forbidden.
