C-Fos Antibody, pAb, Rabbit

Transcription factor C-Fos is one member of Fos family of nuclear oncogenes which includes c-Fos, FosB, Fos-related antigen 1 (FRA1) and Fos-related antigen 2 (FRA2). C-Fos is a major component of the activator protein-1 (AP-1) transcription factor complex and dimerizes with Jun proteins (c-Jun, JunB and JunD) to form AP-1 complex. AP-1 upregulates transcription of a diverse range of genes containing AP-1 regulatory elements. And phosphorylation of c-Fos on serine 32 and threonine 232 by ERK-5 increases protein stability and nuclear localization. C-Fos probably serves as a genetic regulator for cellular mechanisms mediating neuronal excitability and survival vial regulation of kainic acid receptor GLUR6 and expression of brain-derived neurotrophic factor BDNF. GenScript Rabbit Anti-C-Fos Polyclonal Antibody is developed in rabbit using a KLH-coupled synthetic peptide within residues 250~300 of human C-Fos (Swiss Prot: P01100).