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GRP94 Antibody, pAb, Rabbit

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Glucose regulated protein 94 (GRP94) is a resident protein of the endoplasmic reticulum (ER) with highly conserved sequence Lys-Asp-Glu-Leu (KDEL) at its C terminus. The KDEL sequence appears to be necessary for retention and appears to be sufficient to reduce the secretion of proteins from the ER. GRP94 can serve as molecular chaperone that functions in the processing and transport of secreted proteins. It might be associated transiently with a variety of newly synthesized secretory and membrane proteins or permanently with mutant or defective proteins.
A01510
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Specificity GenScript Rabbit Anti-GRP94 Polyclonal Antibody detects endogenous levels of human GRP94. Predicted to react with mouse and rat GRP94 according to sequence homology.
Host Species Rabbit
Immunogen KLH-coupled synthetic peptide within residues 380~430 of human GRP94 (Swiss Prot: P14625).
Species Reactivity Human

Concentration 0.5 mg/ml, lyophilized with PBS, pH 7.4, containing 0.02% sodium azide.
Reconstitution Reconstitute the lyophilized powder with deionized water (or equivalent) to an final concentration of 0.5 mg/ml.
Purification Immunoaffinity chromatography.

Target Background Glucose regulated protein 94 (GRP94) is a resident protein of the endoplasmic reticulum (ER) with highly conserved sequence Lys-Asp-Glu-Leu (KDEL) at its C terminus. The KDEL sequence appears to be necessary for retention and appears to be sufficient to reduce the secretion of proteins from the ER. GRP94 can serve as molecular chaperone that functions in the processing and transport of secreted proteins. It might be associated transiently with a variety of newly synthesized secretory and membrane proteins or permanently with mutant or defective proteins.
Synonyms Rabbit Anti-GRP94 polyclonal antibody; Endoplasmin antibody

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