Ki-67 Antibody, pAb, Rabbit

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Ki-67 is a nuclear antigen expressed in proliferating cells but not in quiescent cells. Expression of this antigen occurs preferentially during late G1, S, G2, and M phases of the cell cycle. While in cells in G0 phase, the antigen cannot be detected. Ki-67 protein serves as biomarker in tumor pathology to detect proliferating cells in neoplastic diseases. Ki-67 protein contains potential nuclear targeting signals for about 200 potential phosphorylation sites, 19 N-myristoylation sites, and 3 amidation sites. Ki-67 antibodies are useful in establishing the cell growing fraction in neoplasms (immunohistochemically quantified by determining the number of Ki-67 positive cells among the total number of resting cells = Ki-67 index).GenScript Rabbit Anti-Ki-67 Polyclonal Antibody is developed in rabbit using a KLH-coupled synthetic peptide from C-terminal of human Ki-67 protein (Swiss Prot: P46013).

产品编号	A01495
规格	定制报价

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产品概述

Specificity	GenScript Rabbit Anti-Ki-67 Polyclonal Antibody detects endogenous levels of human Ki-67. Positive Control: human carcinoma hepatis tissue slide.
Host Species	Rabbit
Immunogen	KLH-coupled synthetic peptide from C-terminal of human Ki-67 protein (Swiss Prot: P46013).
Species Reactivity	Human

产品属性

Concentration	0.5 mg/ml, lyophilized with PBS, pH 7.4, containing 0.02% sodium azide.
Reconstitution	Reconstitute the lyophilized powder with deionized water (or equivalent) to an antibody concentration of 0.5 mg/ml.
Purification	Immunoaffinity chromatography

技术背景

Target Background

Ki-67 is a nuclear antigen expressed in proliferating cells but not in quiescent cells. Expression of this antigen occurs preferentially during late G1, S, G2, and M phases of the cell cycle. While in cells in G0 phase, the antigen cannot be detected. Ki-67 protein serves as biomarker in tumor pathology to detect proliferating cells in neoplastic diseases. Ki-67 protein contains potential nuclear targeting signals for about 200 potential phosphorylation sites, 19 N-myristoylation sites, and 3 amidation sites. Ki-67 antibodies are useful in establishing the cell growing fraction in neoplasms (immunohistochemically quantified by determining the number of Ki-67 positive cells among the total number of resting cells = Ki-67 index).

GenScript Rabbit Anti-Ki-67 Polyclonal Antibody is developed in rabbit using a KLH-coupled synthetic peptide from C-terminal of human Ki-67 protein (Swiss Prot: P46013).

Synonyms

Ki67 antibody;