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Human RANTES Antibody (1E11E6), mAb, Mouse

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RANTES is a chemoattractant for blood monocytes, memory T helper cells, and eosinophils. It causes the release of histamine from basophils and activates eosinophils and binds to CCR1, CCR3, CCR4, and CCR5. It is also one of the major HIV suppressive factors produced by CD8+ T cells. Recombinant RANTES protein induces a dose dependent inhibition of different strains of HIV 1, HIV 2, and simian immunodeficiency virus (SIV). Induced by mitogens, it is T cell and macrophage specific and belongs to the intercrine beta (chemokine CC) family.GenScript Human RANTES Antibody (1E11E6), mAb, Mouse is produced from the hybridoma resulting from fusion of Sp2/0 myeloma and lymphocytes obtained from mouse immunized with purified full length recombinant human RANTES protein (Swiss Prot: P13501).
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Specificity GenScript Human RANTES Antibody (1E11E6), mAb, Mouse detects human RANTES protein.
Host Species Mouse
Immunogen Purified full length recombinant human RANTES protein (Swiss Prot: P13501)
Species Reactivity Human. Reactivity to other species is not tested yet.

Concentration 0.5 mg/ml, lyophilized with PBS, pH 7.4, containing 0.02% sodium azide
Reconstitution Reconstitute the lyophilized powder with deionized water (or equivalent) to an antibody concentration of 0.5 mg/ml.
Purification Protein A affinity column
Clone ID 1E11E6

Target Background RANTES is a chemoattractant for blood monocytes, memory T helper cells, and eosinophils. It causes the release of histamine from basophils and activates eosinophils and binds to CCR1, CCR3, CCR4, and CCR5. It is also one of the major HIV suppressive factors produced by CD8+ T cells. Recombinant RANTES protein induces a dose dependent inhibition of different strains of HIV 1, HIV 2, and simian immunodeficiency virus (SIV). Induced by mitogens, it is T cell and macrophage specific and belongs to the intercrine beta (chemokine CC) family.
GenScript Human RANTES Antibody (1E11E6), mAb, Mouse is produced from the hybridoma resulting from fusion of Sp2/0 myeloma and lymphocytes obtained from mouse immunized with purified full length recombinant human RANTES protein (Swiss Prot: P13501).
Synonyms Mouse anti RANTES mAb; Mouse anti CCL5 mAb

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