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Effects of Eugenol on Alzheimer's Disease-like Manifestations in Insulin-and Aβ-Induced Rat Models

Neurophysiology. 2019-07; 
P. Taheri, P. Yaghmaei, H. Sepasi Tehrani & A. Ebrahim-Habibi
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Biochemicals … sunflower oil Chloroform used for euthanasia of the experimental animals was from Merck (Germany), and beta amyloid and insulin were from Genscript (Germany) and Exir Pharmaceutical Company (Iran), respectively Amyloid … Get A Quote

摘要

Eugenol is a phenylpropene having antidepressant properties. We investigated the effect of eugenol on amyloid plaques as a hallmark of Alzheimer’s disease (AD) in two AD rat models. In the latter, betaamyloid (Aβ) and insulin amyloid fibrils were injected into the rat hippocampus. After a one week lapse, the rats were treated with 0.01 and 0.02 mg/kg eugenol for two weeks. Passive avoidance learning and memory performance was assessed by measuring the step-through latency (STL). Amyloid plaques in the hippocampus were quantitatively evaluated and statistically analyzed using image processing software and ANOVA. Aβ amyloid was a more potent inducer of the signs related to Alzheimer’s disease than insulin. ... More

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