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Co-opting the E3 ligase KLHDC2 for targeted protein degradation by small molecules
Authors: Christopher M. Hickey, Katherine M. Digianantonio, Kurt Zimmermann  , Alicia Harbin, Connor Quinn, Avani Patel, Peter Gareiss  , Amanda Chapman1 , Bernadette Tiberi1,2, Jennifer Dobrodziej1,3, John Corradi1 , Angela M. Cacace1 , David R. Langley & Miklós Békés
Journal: NATURE STRUCTURAL & MOLECULAR BIOLOGY
Doi: 10.1038/s41594-023-01146-w
Products & Services: Peptide Synthesis   Gene Synthesis   
Oat Peptides Alleviate Dextran Sulfate Sodium Salt-Induced Colitis by Maintaining the Intestinal Barrier and Modulating the Keap1-Nrf2 Axis
Authors: Zhong-Hao Ji, Wen-Yin Xie , Pei-Sen Zhao , Hong-Yu Wu , Wen-Zhi Ren , Jin-Ping Hu , Wei Gao , Bao Yuan
Journal: Nutrients .
PubMed ID: 38140314
Doi: 10.3390/nu15245055
Products & Services: Peptide Synthesis   
Serine-129 phosphorylation of α-synuclein is an activity-dependent trigger for physiologic protein-protein interactions and synaptic function
Authors: Leonardo A Parra-Rivas , Kayalvizhi Madhivanan , Brent D Aulston , Lina Wang , Dube Dheeraj Prakashchand , Nicholas P Boyer , Veronica M Saia-Cereda , Kristen Branes-Guerrero , Donald P Pizzo , Pritha Bagchi , V S Sundar , Yong Tang , Utpal Das , David A Scott , Padmini Rangamani , Yuki Ogawa , Subhojit Roy
Journal: Neuron .
PubMed ID: 38128479
Doi: 10.1016/j.neuron.2023.11.020
Products & Services: Gene Services   
Staphylococcus aureus functional amyloids catalyze degradation of β-lactam antibiotics
Authors: Elad Arad , Kasper B Pedersen , Orit Malka, Sisira Mambram Kunnath , Nimrod Golan , Polina Aibinder , Birgit Schiøtt , Hanna Rapaport, Meytal Landau , Raz Jelinek
Journal: Nat Commun .
PubMed ID: 38081813
Doi: s41467-023-43624-1
Products & Services: Peptide Synthesis   
Molecular mechanism of allosteric activation of the CRISPR ribonuclease Csm6 by cyclic tetra-adenylate
Authors: Liyang Du , Qinwei Zhu & Zhonghui Lin
Journal: The EMBO Journal
Doi: 10.1038/s44318-023-00017-w
Products & Services: Gene Synthesis   
Structural dynamics of the CROPs domain control stability and toxicity of Paeniclostridium sordellii lethal toxin
Authors: Yao Zhou, Xiechao Zhan , Jianhua Luo, Diyin Li , Ruoyu Zhou , Jiahao Zhang , Zhenrui Pan , Yuanyuan Zhang , Tianhui Jia , Xiaofeng Zhang , Yanyan Li , Liang Tao
Journal: Nat Commun .
PubMed ID: 38114525
Doi: 10.1038/s41467-023-44169-z
Products & Services: Codon Optimization   
Plant-based meat analogues enhance the gastrointestinal motility function and appetite of mice by specific volatile compounds and peptides
Authors: Yunting Xie, Linlin Cai, Mengzhen Ding, Kai Shan, Di Zhao, Guanghong Zhou, Chunbao Li
Journal: Food Research International
Doi: 10.1016/j.foodres.2023.113551
Products & Services: Gene Synthesis   
Shenqi Fuzheng injection restores the sensitivity to gefitinib in non-small cell lung cancer by inhibiting the IL-22 STAT3 AKT pathway
Authors: Jiali Wang , Xianhai He , Zhirong Jia , Aiwen Yan , Kang Xiao , Shuo Liu , Mengjun Hou , Yaling Long , Xuansheng Ding
Journal: Pharm Biol .
PubMed ID: 38100532
Doi: 10.1080/13880209.2023.2292266
Products & Services: PCR Cloning and Subcloning   
A KDPG sensor RccR governs Pseudomonas aeruginosa carbon metabolism and aminoglycoside antibiotic tolerance
Authors: Yujue Wang , Zhipeng Wang , Weizhong Chen , Ze-Hui Ren , Hui Gao , Jiani Dai , Guan-Zheng Luo , Zhaowei Wu , Quanjiang Ji
Journal: Nucleic Acids Res .
PubMed ID: 38096062
Doi: 10.1093/nar/gkad1201
Products & Services: Molecular Biology Reagents   
Synthetic High-Density Lipoprotein-Based Nanomedicine to Silence SOCS1 in Tumor Microenvironment and Trigger Antitumor Immunity against Glioma
Authors: Chunrong Yang , Yujie Li , Yuchen Yang , Qiankun Ni , Zeyu Zhang , Yi Chai , Jinghong Li
Journal: Angew Chem Int Ed Engl .
PubMed ID: 37847126
Doi: 10.1002/anie.202312603
Products & Services: Peptide Synthesis   
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