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Filamentous fungus-produced human monoclonal antibody provides protection against SARS-CoV-2 in hamster and non-human primate models

Authors: Franziska K Kaiser, Mariana Gonzalez Hernandez, Nadine Krüger, Ellinor Englund, Wenjuan Du, Anna Z Mykytyn, Mathijs P Raadsen, Mart M Lamers

Journal: Nature Communications

PubMed ID: 38485931

Doi: 10.1038/s41467-024-46443-0

Products & Services: Codon Optimization

Alternative low-populated conformations prompt phase transitions in polyalanine repeat expansions

Authors: Rosa Antón, Miguel Á Treviño, David Pantoja-Uceda, Sara Félix, María Babu, Eurico J Cabrita, Markus Zweckstetter, Philip Tinnefeld, Andrés M Vera, Javier Oroz

Journal: Nature

PubMed ID: 38431667

Doi: 10.1038/s41467-024-46236-5

Products & Services: Gene Synthesis

An alphacoronavirus polymerase structure reveals conserved replication factor functions

Authors: Thomas K Anderson, Peter J Hoferle, Kennan J Chojnacki, Kenneth W Lee, Joshua J Coon, Robert N Kirchdoerfer

Journal: Nucleic Acids Research

PubMed ID: 38442273

Doi: 10.1093/nar/gkae153

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Determinants of CRISPR Cas12a nuclease activation by DNA and RNA targets

Authors: Eric A Nalefski, Remy M Kooistra, Ishira Parikh, Samantha Hedley, Karunya Rajaraman, Damian Madan

Journal: Nucleic Acids Research

PubMed ID: 38477377

Doi: 10.1093/nar/gkae152

Products & Services: Gene Synthesis

Biochemical and structural analysis of N-myristoyltransferase mediated protein tagging

Authors: Paul Monassa , Frédéric Rivière , Cyril Dian , Frédéric Frottin , Carmela Giglione , Thierry Meinnel

Journal: Methods Enzymol .

PubMed ID: 37230587

Doi: 10.1016/bs.mie.2023.02.016

Products & Services: Peptide Synthesis

Kinetic and catalytic features of N-myristoyltransferases

Authors: Frédéric Rivière , Paul Monassa , Carmela Giglione , Thierry Meinnel

Journal: Methods Enzymol .

PubMed ID: 37230588

Doi: 10.1016/bs.mie.2023.02.018

Products & Services: Peptide Synthesis

ARGLU1 enhances promoter-proximal pausing of RNA polymerase II and stimulates DNA damage repair

Authors: Scott Bachus, Nikolas Akkerman, Lauren Fulham, Drayson Graves, Rafe Helwer, Jordan Rempel, Peter Pelka

Journal: Nucleic Acids Research

PubMed ID: 38520408

Doi: 10.1093/nar/gkae208

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DNA fragility at topologically associated domain boundaries is promoted by alternative DNA secondary structure and topoisomerase II activity

Authors: Heather M Raimer Young, Pei-Chi Hou, Anna R Bartosik, Naomi D Atkin, Lixin Wang, Zhenjia Wang, Aakrosh Ratan, Chongzhi Zang, Yuh-Hwa Wang

Journal: Nucleic Acids Research

PubMed ID: 38452213

Doi: 10.1093/nar/gkae164

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MiR-326 sponges TET2 triggering imbalance of Th17/Treg differentiation to exacerbate pyroptosis of hepatocytes in concanavalin A-induced autoimmune hepatitis

Authors: Genglin Zhang, Sensen Wu, Guangtao Xia

Journal: Hepatology

PubMed ID: 38043702

Doi: 10.1016/j.aohep.2023.101183

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Humanin variant P3S is associated with longevity in APOE4 carriers and resists APOE4-induced brain pathology

Authors: Brendan Miller, Su-Jeong Kim, Kevin Cao, Hemal H Mehta, Neehar Thumaty, Hiroshi Kumagai, Tomomitsu Iida, Cassandra McGill, Christian J Pike, Kamila Nurmakova, Zachary A Levine, Patrick M Sullivan, Kelvin Yen, Nilüfer Ertekin-Taner, Gil Atzmon, Nir Barzilai, Pinchas Cohen

Journal: Cell

PubMed ID: 38520065

Doi: 10.1111/acel.14153

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