SARS-CoV-2 Spike protein (S1, E484Q, L452R, His Tag)

该产品已下架。

SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) also known as 2019-nCoV (2019 Novel Coronavirus) is a virus that causes illnesses ranging from the common cold to severe diseases. Lineage B.1.617, also known as G/452.V3, was first identified in October 2020 in India. This variant has the double mutations E484Q and L452R in the spike proteins. Emerging research suggests the variant may be more transmissible than previously evolved ones. Whether the effectiveness of currently-deployed vaccines is affected remains under investigation. Moreover, the sublineages B.1.617.2 has been redesignated as "variant of concern" (VOC-21APR-02) in May 2021, which spreads more quickly than the original version of the virus.

产品编号	Z03609
规格	定制报价

联系我们

产品简介

Species

SARS-CoV-2

Protein Construction

S1 protein [Gln14-Arg685 (E484Q, L452R)] Accession # P0DTC2	Poly-His
N-term	C-term

Purity

≥ 95% as analyzed by SDS-PAGE

Endotoxin Level

< 0.2 EU/μg of protein by gel clotting method

Biological Activity

This protein is validated to bind with human ACE2 in functional ELISA assay.

Expression System

CHO

Theoretical Molecular Weight

75.7 kDa

Formulation

Supplied as a solution in PBS, pH 7.4.

Concentration

Please refer to the COA for the specific lot.

Storage & Stability

Upon receiving, this product remains stable for up to 6 months at -20°C or below. Please avoid repeated freeze-thaw cycles.

技术背景

Target Background	SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) also known as 2019-nCoV (2019 Novel Coronavirus) is a virus that causes illnesses ranging from the common cold to severe diseases. Lineage B.1.617, also known as G/452.V3, was first identified in October 2020 in India. This variant has the double mutations E484Q and L452R in the spike proteins. Emerging research suggests the variant may be more transmissible than previously evolved ones. Whether the effectiveness of currently-deployed vaccines is affected remains under investigation. Moreover, the sublineages B.1.617.2 has been redesignated as "variant of concern" (VOC-21APR-02) in May 2021, which spreads more quickly than the original version of the virus.
Synonyms	Lineage B.1.617; G/452.V3; “double mutation" variant; India variant; Kappa variant
References	1. COVID-19 Weekly Epidemiological Update. 2. Transmission, infectivity, and neutralization of a spike L452R SARS-CoV-2 variant. 3. SARS-CoV-2 variants of concern and variants under investigation in England.