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S100A6, His, Human

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S100 calcium-binding protein A6 (S100A6) is a small calcium binding protein with 2 EF-hand structures and belongs to the S100 family. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 proteins include at least 25 members which are located as a cluster on chromosome 1q21. S100A6 protein may function in stimulation of Ca2+-dependent insulin release, stimulation of prolactin secretion, and exocytosis. Chromosomal rearrangements and altered expression of this gene have been implicated in melanoma.Recombinant S100 calcium-binding protein A6 (S100A6) with His tag produced in E. coli is a single chain containing 97 amino acids with molecular mass of 11.1 kDa analyzed by reducing SDS-PAGE and is obtained by chromatographic techniques at GenScript.
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产品简介
Species Human
Purity > 95% as analyzed by SDS-PAGE.
Endotoxin Level < 1 EU/μg, determined by LAL method.
Formulation Lyophilized after extensive dialysis against 50mM Tris-HCl, 100mM NaCI, 0.5mM PMSF, 1mM TCEP, pH8.0.
Reconstitution Reconstituted in ddH2O at 200 μg/ml.

技术背景
Target Background S100 calcium-binding protein A6 (S100A6) is a small calcium binding protein with 2 EF-hand structures and belongs to the S100 family. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 proteins include at least 25 members which are located as a cluster on chromosome 1q21. S100A6 protein may function in stimulation of Ca2+-dependent insulin release, stimulation of prolactin secretion, and exocytosis. Chromosomal rearrangements and altered expression of this gene have been implicated in melanoma.
Recombinant S100 calcium-binding protein A6 (S100A6) with His tag produced in E. coli is a single chain containing 97 amino acids with molecular mass of 11.1 kDa analyzed by reducing SDS-PAGE and is obtained by chromatographic techniques at GenScript.
Synonyms Protein S100-A6, Calcyclin, Growth factor-inducible protein 2A9, MLN 4, Prolactin receptor-associated protein, PRA, S100 calcium-binding protein A6, S100A6, CACY, 2A9, 5B10, CABP

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