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S100A4, Human

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S100 calcium-binding protein A4 (S100A4) is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100A4 promotes metastasis in several experimental animal models, and S100A4 protein expression is associated with differential patient outcome in a number of tumor types. S100A4 is localized in the nucleus, cytoplasm, and extracellular space and possesses a wide range of biological functions such as regulation of angiogenesis, cell survival, motility, and invasion.Recombinant S100 calcium-binding protein A4 (S100A4) produced in E. coli is a single chain containing 101 amino acids with molecular mass of 11.7 kDa analyzed by reducing SDS-PAGE and is obtained by chromatographic techniques at GenScript.
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产品简介
Species Human
Purity > 90% as analyzed by SDS-PAGE.
Endotoxin Level < 1 EU/μg, determined by LAL method.
Formulation Lyophilized after extensive dialysis against 20 mM Tris-HCl, 100 mM NaCl , pH8.0.
Reconstitution Reconstituted in ddH2O at 200 μg/ml.

技术背景
Target Background S100 calcium-binding protein A4 (S100A4) is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100A4 promotes metastasis in several experimental animal models, and S100A4 protein expression is associated with differential patient outcome in a number of tumor types. S100A4 is localized in the nucleus, cytoplasm, and extracellular space and possesses a wide range of biological functions such as regulation of angiogenesis, cell survival, motility, and invasion.
Recombinant S100 calcium-binding protein A4 (S100A4) produced in E. coli is a single chain containing 101 amino acids with molecular mass of 11.7 kDa analyzed by reducing SDS-PAGE and is obtained by chromatographic techniques at GenScript.
Synonyms Protein S100-A4, S100 calcium-binding protein A4, Metastasin, Protein Mts1, Placental calcium-binding protein, Calvasculin, S100A4, CAPL, MTS1, 42A, 18A2, FSP1, P9KA, PEL98.

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