UBE2B/HR6B, His, Human

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Ubiquitinconjugating Enzyme E2 B (UBE2B), also referred to as Homolog of Rad6B (HR6B), is a member of the Ubiquitinconjugating (E2) enzyme family. It has apredicted molecular weight of 17 kDa, and is highly expressed in the brain, heart, andtestis. UBE2B forms a thioester bond with ubiquitin through a cysteine residue in its catalytic core domain.Studies indicate that UBE2B may play a critical role in male fertility and overexpression may be linked to certain types of cancer.Recombinant Human UBE2B produced in E. coli cells is a single non-glycosylated polypeptide chain containing 159 amino acids. A fully biologically active molecule, rhUBE2B has a molecular mass of 18.3 kDa analyzed by reducing SDS-PAGE and is obtained by chromatographic techniques at GenScript.

产品编号	Z02967
规格	定制报价

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产品简介

Purity	> 95% as analyzed by SDS-PAGE&HPLC.
Endotoxin Level	< 0.2 EU/μg, determined by LAL method.
Formulation	yophilized after extensive dialysis against PBS.
Reconstitution	Reconstituted in ddH₂O or PBS at 100 μg/ml.

技术背景

Target Background

Ubiquitinconjugating Enzyme E2 B (UBE2B), also referred to as Homolog of Rad6B (HR6B), is a member of the Ubiquitinconjugating (E2) enzyme family. It has apredicted molecular weight of 17 kDa, and is highly expressed in the brain, heart, andtestis. UBE2B forms a thioester bond with ubiquitin through a cysteine residue in its catalytic core domain.Studies indicate that UBE2B may play a critical role in male fertility and overexpression may be linked to certain types of cancer.
Recombinant Human UBE2B produced in E. coli cells is a single non-glycosylated polypeptide chain containing 159 amino acids. A fully biologically active molecule, rhUBE2B has a molecular mass of 18.3 kDa analyzed by reducing SDS-PAGE and is obtained by chromatographic techniques at GenScript.

Synonyms

Human HR6B; Human UBE2B; Ubiquitin-conjugating enzyme E2 B