| Species |
Rat |
| Protein Construction |
Expressed with an N-terminal Met.
CCL24 (Pro23-Val119)
Accession # Q5PPP2 |
|
| Purity |
> 96% as analyzed by SDS-PAGE
> 96% as analyzed by HPLC |
| Endotoxin Level |
< 1 EU/μg of protein by LAL method |
| Biological Activity |
Fully biologically active when compared to standard. The biologically active determined by a chemotaxis bioassay using human peripheral blood eosinophils is in a concentration of 50.0-250.0 ng/ml. |
| Expression System |
E. coli |
| Theoretical Molecular Weight |
10.5 kDa |
| Formulation |
Lyophilized from a 0.2 μm filtered solution in 2 × PBS, pH 7.4. |
| Reconstitution |
It is recommended that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute the lyophilized powder in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/ml. |
| Storage & Stability |
Upon receiving, this product remains stable for up to 6 months at -70°C or -20°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C. Avoid repeated freeze-thaw cycles. |
| Target Background |
Eotaxin-2/CCL24, also named MPIF-2 and Ckβ6, is a novel CC chemokine recently identified. It is produced by activated monocytes and T lymphocytes. Eotaxin-2 selectively chemoattracts cells expressing CCR3 including eosinophils, basophils, Th2 T cells, mast cells, and certain subsets of dendritic cells. Additionally, Eotaxin-2 inhibits the proliferation of multipotential hematopoietic progenitor cells. The mature protein, which also includes a C-terminal truncation, contains 78 amino acid residues (92 a.a. residues for the mouse homolog, without C-terminal truncation). |
| Synonyms |
C-C motif chemokine 24; CK-beta-6; Eosinophil chemotactic protein 2; Myeloid progenitor inhibitory factor 2; MPIF-2; Small-inducible cytokine A24; MPIF2; SCYA24 |
For laboratory research use only. Direct human use, including taking orally and injection and clinical use are forbidden.
