| Species |
Mouse |
| Protein Construction |
MIP-3β (Gly26-Ser108)
Accession # O70460 |
|
| Purity |
> 97% as analyzed by SDS-PAGE
> 97% as analyzed by HPLC |
| Endotoxin Level |
< 1 EU/μg of protein by LAL method |
| Biological Activity |
Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human mature dendritic cells is in a concentration range of 10.0-100.0 ng/ml. |
| Expression System |
E. coli |
| Theoretical Molecular Weight |
9.2 kDa |
| Formulation |
Lyophilized from a 0.2 μm filtered solution in PBS, pH 7.4. |
| Reconstitution |
It is recommended that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute the lyophilized powder in sterile distilled water or aqueous buffer containing 0.1 % BSA to a concentration of 0.1-1.0 mg/ml. |
| Storage & Stability |
Upon receiving, this product remains stable for up to 6 months at -70°C or -20°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C. Avoid repeated freeze-thaw cycles. |
| Target Background |
Chemokine (C-C motif) ligand 19 (CCL19) is a small cytokine belonging to the CC chemokine family that is also known as EBI1 ligand chemokine (ELC) and macrophage inflammatory protein-3-beta (MIP-3-beta). It binds specifically to the chemokine receptor CCR7 / EBI1 / BLR2. CCL19 is expressed abundantly in thymus, lymph nodes and in activated bone marrow stromal cells. It attracts certain cells of the immune system, including dendritic cells and antigen-engaged B cells, CCR7+ central-memory T-Cells. |
| Synonyms |
CCL-19; CKb11; ELC; MIP-3b; MIP3B; SCYA19; C-C motif chemokine ligand 19 |
For laboratory research use only. Direct human use, including taking orally and injection and clinical use are forbidden.
