MIP-2/CXCL2, Mouse

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Macrophage Inflammatory Protein 2 (MIP-2) was originally identified as a heparin binding protein secreted from a mouse macrophage cell line in response to endotoxin stimulation. Based on its protein and DNA sequences, MIP-2 is a member of the alpha (CXC) subfamily of chemokines.Similarly to other alpha chemokines, mouse MIP-2 is a potent neutrophil attractant and activator. MIP-2 and KC can bind the mouse interleukin 8 type B receptor homologue with high affinity. The expression of MIP-2 was found to be associated with neutrophil influx in pulmonary inflammation and glomerulonephritis, suggesting that MIP-2 may contribute to the pathogenesis of inflammatory diseases.

产品编号	Z02850
规格	定制报价

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产品简介

Species

Mouse

Protein Construction

MIP-2 (Ala28-Asn100)
Accession # P10889

Purity

> 97% as analyzed by SDS-PAGE
> 97% as analyzed by HPLC

Endotoxin Level

< 1 EU/μg of protein by LAL method

Biological Activity

Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human neutrophils is in a concentration range of 1.0-10.0 ng/ml.

Expression System

E. coli

Theoretical Molecular Weight

7.8 kDa

Formulation

Lyophilized from a 0.2 μm filtered solution in 20 mM PB, pH 7.4, 150 mM NaCl.

Reconstitution

It is recommended that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute the lyophilized powder in sterile distilled water or aqueous buffer containing 0.1 % BSA to a concentration of 0.1-1.0 mg/ml.

Storage & Stability

Upon receiving, this product remains stable for up to 6 months at -70°C or -20°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C. Avoid repeated freeze-thaw cycles.

技术背景

Target Background

Synonyms

SCYB2; GRO2; GROb; MIP-2a; MGSA-b; CINC-2a; MGSA beta

For laboratory research use only. Direct human use, including taking orally and injection and clinical use are forbidden.