IL-25, Mouse
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Interleukin-25 (IL-25), also known as interleukin-17E (IL-17E), is a cytokine that belongs to the IL-17 cytokine family together with IL-17A (named also IL-17), IL-17B, IL-17C, IL-17D and IL-17F. IL-25 has a heterodimeric receptor. The receptor is composed of two subunits IL-17RA and IL-17RB, it does not bind directly to IL-17RA, but this subunit is necessary for its functions, as well as IL-17RB which directly bind IL-25. IL-25 can induce NF-κB activation, and stimulate the production of IL-8 (named also CXCL8), which is the major chemotactic substance of neutrophils. Another important function of IL-25 is to support the Th2 immune response. IL-25 has been shown to induce the production of IL-4, IL-5 and IL-13. Evidence is the expression of IL-17RB on Th2 cells, not on Th1 and Th17. In addition, IL-25 is responsible for the decrease in IFN gamma.
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