| Catalog No. |
Size(µg) |
Price(￥) |
Figures |
A00089
|
100
|
2849.00
|
EXAMPLE:
|
|
Khoshnan A, et al. Effects of intracellular expression of anti-huntingtin antibodies of various specificities on mutant huntingtin aggregation and toxicity. Proc. Natl. Acad Sci. U. S. A. Jan 2002; 99(2): 1002-1007.
|
|
Ko J, et al. New anti-huntingtin monoclonal antibodies: implications for huntingtin conformation and its binding proteins. Brain Res. Bull. Oct-Nov 2001; 56(3-4): 319-329.
|
|
| Full Name
|
| Huntingtin Antibody, mAb, Mouse
|
|
| abbreviated_name1
| Mouse Anti-Huntingtin mAb
|
| abbreviated_name2
| Anti Huntingtin (monoclonal)
|
| Ig Subclass
| Mouse monoclonal (IgG1)
|
| Storage
| The antibody will remain stable for one year from the date of shipment if stored at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing. The aliquot will be remain stable for three months if stored at 4°C.
|
| Specificity
| Recognize hungtingtin from human and mouse
|
| Concentration
| 1 mg/ml in PBS, pH 7.4 with 0.05% sodium azide, frozen liquid
|
| Immunogen
| N-terminal peptides 1-225 aa
|
| Purification Method
| Immunoaffinity purification
|
| Applications
| Western blot and IHC in lipid metabolic research. Huntingtin is a 350,000 Da protein that is mutated in Huntington's disease (HD). The normal function of huntingtin still remains uncertain but it has been suggested that it performs a necessary housekeeping function. The abnormal form of huntingtin aggregates in vitro and forms neuronal intranuclear and cytoplasmic inclusions in HD patients. This antibody detects a 350,000 Da band on Western blots but also detects smaller degradation products of huntingtin in some tissue lysates.
|
| Conjugation
| Unconjugated
|
| Host Species
| Mouse
|
| Note
| Briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container's cap because small volumes of antibody will occasionally become entrapped in the seal of the product vial during shipment and storage.
|
