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N-Acetyl-Ser-Asp-Lys-Pro

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Acetyl Ser-Asp-Lys-Pro is formed in bone marrow cells by enzymatic processing of thymosin β4. It inhibits the entry of pluripotent hemopoietic stem cells into S-phase of the cell cycle and protects against Ara-C lethality in mice. Acetyl Ser-Asp-Lys-Pro is also a specific substrate for the N-terminal active site of angiotensin-converting enzyme, which is responsible for its degradation in vivo.
RP10555
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Synonyms AcSDKP; Ac-S-D-K-P
Description Acetyl Ser-Asp-Lys-Pro is formed in bone marrow cells by enzymatic processing of thymosin β4. It inhibits the entry of pluripotent hemopoietic stem cells into S-phase of the cell cycle and protects against Ara-C lethality in mice. Acetyl Ser-Asp-Lys-Pro is also a specific substrate for the N-terminal active site of angiotensin-converting enzyme, which is responsible for its degradation in vivo.
Cas No 127103-11-1
Sequence
{SER}{ASP}{LYS}{PRO}
Sequence Shortening SDKP
Molecular Formula C20H33N5O9
N Terminal AC
Molecular Weight 487.5

Purity > 95%
Form Lyophilized
Storage Store at -20°C.
Note (CFU-S = Spleen Colony-Forming Units) N-Acetyl-Ser-Asp-Lys-Pro exerts a high inhibitory activity on the proliferation of hematopoietic pluripotent stem cells

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