GPCR药物筛选及分析服务
G蛋白偶联受体(G protein-coupled receptor，GPCR) 包含600-1000个成员，是极重要的药物治疗靶点。临床上很多药物是通过作用于GPCRs，达到治疗疼痛、哮喘、高血压以及免疫系统和神经系统相关疾病的疗效。
为满足GPCR药物筛选及分析(GPCR screening and profiling)的需求，金斯瑞不仅提供种类齐全的GPCR细胞库和母细胞系，也提供订制GPCR细胞系的服务。我们凭借先进的设备和分析平台，为您提供基于生化与细胞水平的GPCR药物筛选方案，如GPCR激动剂筛选、GPCR拮抗剂（抑制剂）筛选等，加速您的药物研发进程。
金斯瑞不仅可直接提供目录上多种稳定细胞系产品，还能为您提供全面的基因、蛋白、多肽和抗体等生物研究试剂服务，进一步帮助您加速药物研发过程。
| 服务编号 |
服务名称 |
价格(￥) |
|
SC1402 |
GPCR药物筛选及分析服务 |
询价 |
免费的化合物筛选服务!
说明:
- 仅限一种G蛋白偶联受体药物筛选模型，最多100个孔
- 超出的部分按照正常价格收费
- 药物筛选模型仅限从我们>150种的细胞水平药物筛选模型中挑选
- 每位客户仅限享受一次, 截止2012年2月29日
服务特色
- 世界上最大的人类G蛋白偶联受体细胞系库
- 充分验证的高通量药物筛选模型
- 最具竞争力的价格
案例展示
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Fig1. 神经肽(Neurokinin B)刺激CHO-K1/NK3细胞和未转染细胞的剂量-反应曲线。Calcium-4试剂与细胞孵育后，用不同浓度的神经激肽B刺激细胞。 FlexStation酶标仪记录钙离子浓度的变化情况。数据表示方法：三次测量的平均值+/-标准差。 |
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Fig2. 精氨酸抗利尿激素(AVP)刺激CHO-K1/V1B细胞和未转染细胞的剂量-反应曲线。Calcium-4试剂与细胞孵育后，用不同浓度的精氨酸抗利尿激素刺激细胞。FlexStation酶标仪记录钙离子浓度的变化情况。数据表示方法：三次测量的平均值+/-标准差。 |
G蛋白偶联受体药物筛选服务和产品
金斯瑞是G蛋白偶联受体创新药物发现和研究方面的专家。金斯瑞建立起了世界上最大的人类G蛋白偶联受体细胞系库。利用这些细胞系，金斯瑞在FLIPRTetra和TopCount药物筛选平台上验证了超过200种高通量药物筛选模型。同时，金斯瑞也供应这些已充分验证过的细胞系和细胞膜产品来满足您的药物研发需求。
请致电联系我们，我们的科学家将为您提供详细的技术解决方案。
超家族 |
配体类型 |
受体家族 |
受体 |
细胞系 |
细胞膜 |
A |
Non-peptide |
Acetylcholine (muscarinic) |
M1 / CHRM1 |
M00185 |
|
A |
Non-peptide |
Acetylcholine (muscarinic) |
M2 / CHRM2 |
M00258 |
M00409 |
A |
Non-peptide |
Acetylcholine (muscarinic) |
M3 / CHRM3 |
M00259 |
M00352 |
A |
Non-peptide |
Acetylcholine (muscarinic) |
M4 / CHRM4 |
M00238 |
M00410 |
A |
Non-peptide |
Acetylcholine (muscarinic) |
M5 / CHRM5 |
M00186 |
M00353 |
A |
Non-peptide |
Adenosine |
ADORA1 |
M00324 |
|
A |
Non-peptide |
Adenosine |
ADORA1 |
M00255 |
|
A |
Non-peptide |
Adenosine |
ADORA2A |
M00246 |
|
A |
Non-peptide |
Adenosine |
ADORA2B |
M00329 |
|
A |
Non-peptide |
Adenosine |
ADORA3 |
M00464 |
|
A |
Non-peptide |
Adrenoceptors |
ADRA1A |
M00225 |
M00354 |
A |
Non-peptide |
Adrenoceptors |
ADRA1B |
M00260 |
M00355 |
A |
Non-peptide |
Adrenoceptors |
ADRA1D |
M00340 |
M00405 |
A |
Non-peptide |
Adrenoceptors |
ADRA2A |
M00281 |
|
A |
Non-peptide |
Adrenoceptors |
ADRA2B |
M00454 |
|
A |
Non-peptide |
Adrenoceptors |
ADRA2C |
M00252 |
|
A |
Non-peptide |
Adrenoceptors |
ADRB1 |
M00269 |
|
A |
Non-peptide |
Adrenoceptors |
ADRB2 |
M00308 |
M00406 |
A |
Non-peptide |
Adrenoceptors |
ADRB3 |
M00335 |
|
A |
Peptide |
Anaphylotoxin |
C5a / C5AR1 |
M00327 |
|
A |
Peptide |
Angiotensin |
AT1 |
M00448 |
|
A |
Peptide |
Angiotensin |
AT1 |
M00458 |
|
A |
Peptide |
Apelin |
AGTRL1 |
M00245 |
|
A |
Non-peptide |
Bile acid |
GPBAR1 |
M00432 |
|
A |
Peptide |
Bombesin |
BB1 / NMBR |
M00254 |
|
A |
Peptide |
Bombesin |
BB2 / GRPR |
M00182 |
|
A |
Peptide |
Bombesin |
BB3 / BRS3 |
M00183 |
|
A |
Peptide |
Bradykinin |
B1 / BDKRB1 |
M00482 |
|
A |
Peptide |
Bradykinin |
B2 / BDKRB2 |
M00184 |
|
A |
Non-peptide |
Cannabinoid |
CB1 / CNR1 |
M00299 |
|
A |
Non-peptide |
Cannabinoid |
CB2 / CNR2 |
M00433 |
|
A |
Peptide |
Chemoattractant |
ChemR23 / CMKLR1 |
M00301 |
|
A |
Peptide |
Cholecystokinin |
CCKA |
M00271 |
|
A |
Peptide |
Cholecystokinin |
CCKB |
M00154 |
|
A |
Non-peptide |
Dopamine |
D1 / DRD1 |
M00247 |
|
A |
Non-peptide |
Dopamine |
D2 / DRD2 |
M00152 |
|
A |
Non-peptide |
Dopamine |
D2S / DRD2S |
M00274 |
M00365 |
A |
Non-peptide |
Dopamine |
D4 / DRD4 |
M00477 |
|
A |
Non-peptide |
Dopamine |
D5 / DRD5 |
M00322 |
M00411 |
A |
Peptide |
Endothelin |
EDNRA |
M00149 |
|
A |
Peptide |
Endothelin |
EDNRB |
M00150 |
|
A |
Non-peptide |
Free Fatty Acid |
FFA1 / GPR40 |
M00273 |
|
A |
Non-peptide |
Free Fatty Acid |
FFA2 / GPR43 |
M00437 |
|
A |
Peptide |
Galanin |
GAL1 |
M00277 |
|
A |
Peptide |
Galanin |
GAL2 |
M00209 |
|
A |
Peptide |
Ghrelin |
GHSR |
M00189 |
|
A |
Peptide |
Gonadotropin-releasing Hormone |
GNRHR |
M00426 |
|
A |
Non-peptide |
Histamine |
H1 |
M00131 |
|
A |
Non-peptide |
Histamine |
H2 |
M00306 |
|
A |
Non-peptide |
Histamine |
H3 |
M00331 |
|
A |
Non-peptide |
Histamine |
H4 |
M00289 |
|
A |
Peptide |
KiSS1-derived Peptide |
KiSS1 / GPR54 |
M00190 |
|
A |
Non-peptide |
Leukotriene |
CysLT1 |
M00462 |
|
A |
Non-peptide |
Leukotriene |
CysLT2 |
M00449 |
|
A |
Non-peptide |
Leukotriene |
LTB4 |
M00435 |
|
A |
Non-peptide |
Leukotriene |
OXE / OXER1 |
M00488 |
|
A |
Non-peptide |
Lysophospholipid |
EDG4 / LPA2 |
M00463 |
|
A |
Non-peptide |
Lysophospholipid |
EDG6 / S1P4 |
M00465 |
|
A |
Peptide |
Melanin-concentrating Hormone |
MCH1 |
M00211 |
|
A |
Peptide |
Melanin-concentrating Hormone |
MCH2 |
M00280 |
|
A |
Peptide |
Melanocortin |
MC2 |
M00336 |
|
A |
Peptide |
Melanocortin |
MC3 |
M00242, M00337 |
|
A |
Peptide |
Melanocortin |
MC4 |
M00272 |
|
A |
Peptide |
Melanocortin |
MC5 |
M00243 |
|
A |
Peptide |
Melatonin |
MT1 / MTNR1A |
M00424 |
|
A |
Peptide |
Melatonin |
MT2 / MTNR1B |
M00312 |
|
A |
Peptide |
Motilin |
MTLR |
M00347 |
|
A |
Peptide |
Neuromedin U |
NMU1 |
M00191 |
|
A |
Peptide |
Neuromedin U |
NMU2 |
M00244 |
|
A |
Peptide |
Neuropeptide B/W |
NPBW1 / GPR7 |
M00452 |
|
A |
Peptide |
Neuropeptide FF |
NPFF1 / GPR147 |
M00431 |
|
A |
Peptide |
Neuropeptide FF |
NPFF2 / GPR74 |
M00474 |
|
A |
Peptide |
Neuropeptide S |
NPS1a |
M00338 |
|
A |
Peptide |
Neuropeptide S |
NPS1b |
M00344 |
|
A |
Peptide |
Neuropeptide Y |
NPY1 |
M00192, M00430 |
|
A |
Peptide |
Neuropeptide Y |
NPY2 |
M00460 |
|
A |
Peptide |
Neuropeptide Y |
NPY4 / PPYR1 |
M00237 |
|
A |
Peptide |
Neurotensin |
NTS1 |
M00194 |
|
A |
Non-peptide |
Nicotinic Acid |
NIACR1 / GPR109A |
M00428 |
|
A |
Peptide |
N-Formyl Peptide |
FPR1 |
M00429 |
|
A |
Peptide |
N-Formyl Peptide |
FPRL1 |
M00305 |
|
A |
Peptide |
Opioid |
OPRD1 |
M00323 |
M00420 |
A |
Peptide |
Opioid |
OPRK1 |
M00290 |
|
A |
Peptide |
Opioid |
OPRL1 |
M00447 |
|
A |
Peptide |
Opioid |
OPRM1 |
M00304 |
|
A |
Peptide |
Orexin |
OX1 |
M00224 |
|
A |
Peptide |
Orexin |
OX2 |
M00316 |
|
A |
Peptide |
Oxytocin |
OT / OXTR |
M00195 |
|
A |
Peptide |
Peptide P518 |
GPR103 |
M00321 |
|
A |
Non-peptide |
Platelet Activating Factor |
PAF / PTAFR |
M00262 |
|
A |
Peptide |
Prolactin Releasing Peptide |
PRLHR |
M00341 |
|
A |
Non-peptide |
Prostanoid |
DP1 / PTGDR |
M00453 |
|
A |
Non-peptide |
Prostanoid |
DP2 / GPR44 |
M00436 |
|
A |
Non-peptide |
Prostanoid |
FP / PTGFR |
M00155 |
|
A |
Non-peptide |
Prostanoid |
EP1 / PTGER1 |
M00228 |
|
A |
Non-peptide |
Prostanoid |
EP2 / PTGER2 |
M00311 |
|
A |
Non-peptide |
Prostanoid |
EP4 / PTGER4 |
M00485 |
|
A |
Non-peptide |
Prostanoid |
IP1 / PTGIR |
M00310 |
|
A |
Non-peptide |
Prostanoid |
TP / TBXA2R |
M00309 |
|
A |
Peptide |
Proteinase-activated Receptor |
PAR2 / F2RL1 |
M00446 |
|
A |
Peptide |
Proteinase-activated Receptor |
PAR4 / F2RL3 |
M00206 |
|
A |
Non-peptide |
Proton-sensor |
GPR68 |
M00439 |
|
A |
Non-peptide |
Purinergic |
P2Y1 |
M00250 |
|
A |
Non-peptide |
Purinergic |
P2Y2 |
M00318 |
|
A |
Non-peptide |
Purinergic |
P2Y4 |
M00297 |
|
A |
Non-peptide |
Purinergic |
P2Y6 |
M00346 |
|
A |
Non-peptide |
Purinergic |
P2Y11 |
M00298 |
|
A |
Non-peptide |
Purinergic |
P2Y12 |
M00261 |
|
A |
Non-peptide |
Serotonin |
5-HT1A / HTR1A |
M00330 |
M00407 |
A |
Non-peptide |
Serotonin |
5-HT2A / HTR2A |
M00251 |
|
A |
Non-peptide |
Serotonin |
5-HT2B / HTR2B |
M00249 |
|
A |
Non-peptide |
Serotonin |
5-HT2C / HTR2C |
M00253, M00319 |
M00391 |
A |
Non-peptide |
Serotonin |
5-HT4 / HTR4 |
M00444 |
|
A |
Non-peptide |
Serotonin |
5-HT7 / HTR7 |
M00423 |
M00416 |
A |
Peptide |
Somatostatin |
SST1 |
M00473 |
|
A |
Peptide |
Somatostatin |
SST2 |
M00325 |
|
A |
Peptide |
Somatostatin |
SST3 |
M00285 |
|
A |
Peptide |
Somatostatin |
SST4 |
M00334 |
|
A |
Peptide |
Somatostatin |
SST5 |
M00286 |
|
A |
Peptide |
Tachykinin |
NK1 / TACR1 |
M00199 |
|
A |
Peptide |
Tachykinin |
NK2 / TACR2 |
M00200 |
|
A |
Peptide |
Tachykinin |
NK3 / TACR3 |
M00201 |
|
A |
Peptide |
Thyrtropin-releasing Hormone |
TRH1 |
M00202 |
|
A |
Peptide |
Urotensin |
UT2 |
M00339 |
|
A |
Peptide |
Vasopressin |
V1A / AVPR1A |
M00181 |
|
A |
Peptide |
Vasopressin |
V1B / AVPR1B |
M00205 |
M00401 |
A |
Peptide |
Vasopressin |
V2 / AVPR2 |
M00170 |
M00417 |
A |
|
Orphan |
GPR120 |
M00440 |
|
A |
|
Orphan |
MRGD / MRGPRD |
M00467 |
|
A |
|
Orphan |
MRGX2 / MRGPRX2 |
M00425 |
|
A |
|
Orphan |
OXGR1 |
M00483 |
|
A |
|
Orphan |
P2Y5 |
M00472 |
|
A |
|
Orphan |
SUCNR1 / GPR91 |
M00471 |
|
B |
Peptide |
Calcitonin |
CALCR / CT |
M00320 |
|
B |
Peptide |
Calcitonin |
AMY1 (RAMP1 + CALCR) |
M00350 |
|
B |
Peptide |
Calcitonin |
AMY1 (RAMP1 + CALCR) |
M00475 |
|
B |
Peptide |
Calcitonin |
AMY2 (RAMP2 + CALCR) |
M00478 |
|
B |
Peptide |
Calcitonin |
AMY3 (RAMP3 + CALCR) |
M00481 |
|
B |
Peptide |
Calcitonin |
AM1 (RAMP2 + CALCRL) |
M00450 |
|
B |
Peptide |
Calcitonin |
AM2 (RAMP3 + CALCRL) |
M00479 |
|
B |
Peptide |
Corticotropin Releasing Factor |
CRF1 |
M00343 |
|
B |
Peptide |
Corticotropin Releasing Factor |
CRF2 |
M00208 |
|
B |
Peptide |
Glucagon |
GCGR |
M00345 |
|
B |
Peptide |
Glucagon |
GCGR |
M00422 |
|
B |
Peptide |
Glucagon |
GHRH |
M00314 |
|
B |
Peptide |
Glucagon |
GIP |
M00486 |
|
B |
Peptide |
Glucagon |
GLP1 |
M00451 |
|
B |
Peptide |
Glucagon |
GLP2 |
M00307 |
|
B |
Peptide |
Glucagon |
SCTR |
M00326 |
|
B |
Peptide |
Parathyroid Hormone |
PTH1 |
M00315 |
|
B |
Peptide |
Parathyroid Hormone |
PTH2 |
M00270 |
|
B |
Peptide |
VIP / PACAP |
PAC1 |
M00203 |
|
B |
Peptide |
VIP / PACAP |
VPAC1 |
M00342 |
|
B |
Peptide |
VIP / PACAP |
VPAC2 |
M00226 |
|
C |
Non-peptide |
Calcium-sensor |
CASR |
M00434 |
|
C |
Non-peptide |
Glutamate |
mGlu2 / GRM2 |
M00427 |
|
| |
|
Control |
|
M00187 |
|
| |
|
Control |
|
M00188 |
|
| |
|
Control |
|
M00257 |
|
| |
|
Control |
|
M00455 |
|
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