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Human CT-1 Antibody (1C12C11), mAb, Mouse

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Cardiotrophin-1 (CT-1) is a member of the cytokine family which also includes IL-6, IL-11, leukemia inhibitory factor (LIF), oncostatin M (OSM), and ciliary neurotrophic factor (CNTF). It was originally isolated based on its ability to induce cardiac myocyte hypertrophy in vitro. CT-1 has since been shown to be a pleiotrophic cytokine with overlapping actions with other IL-6 family members on a variety of cell types. Human CT-1 encodes a 201 amino acid (aa) residue protein that lacks a hydrophobic signal peptide. CT-1 is highly expressed in heart, skeletal muscle, liver, lung, and kidney. Lower level of CT-1 expression is also seen in testis and brain. CT-1 initiates downstream signaling pathways through the heterodimerization of gp130 and the LIF receptor β subunit. A third α receptor subunit has recently been implicated in the receptor complex. GenScript Human CT-1 Antibody (1C12C11), mAb, Mouse is produced from the hybridoma resulting from fusion of Sp2/0 myeloma and lymphocytes obtained from mouse immunized with purified full length recombinant human CT-1 protein (Swiss Prot: Q16619).
A01535
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Specificity No cross-reactivity with other proteins detected.
Host Species Mouse
Immunogen Purified full length human recombinant CT-1 protein (Swiss Prot: Q16619)

Concentration 0.5 mg/ml, lyophilized with PBS, pH 7.4, containing 0.02% sodium azide
Reconstitution Reconstitute the lyophilized powder with deionized water (or equivalent) to an final concentration of 0.5 mg/ml.
Purification Protein A affinity column
Clone ID 1C12C11

Target Background Cardiotrophin-1 (CT-1) is a member of the cytokine family which also includes IL-6, IL-11, leukemia inhibitory factor (LIF), oncostatin M (OSM), and ciliary neurotrophic factor (CNTF). It was originally isolated based on its ability to induce cardiac myocyte hypertrophy in vitro. CT-1 has since been shown to be a pleiotrophic cytokine with overlapping actions with other IL-6 family members on a variety of cell types. Human CT-1 encodes a 201 amino acid (aa) residue protein that lacks a hydrophobic signal peptide. CT-1 is highly expressed in heart, skeletal muscle, liver, lung, and kidney. Lower level of CT-1 expression is also seen in testis and brain. CT-1 initiates downstream signaling pathways through the heterodimerization of gp130 and the LIF receptor β subunit. A third α receptor subunit has recently been implicated in the receptor complex.
GenScript Human CT-1 Antibody (1C12C11), mAb, Mouse is produced from the hybridoma resulting from fusion of Sp2/0 myeloma and lymphocytes obtained from mouse immunized with purified full length recombinant human CT-1 protein (Swiss Prot: Q16619).
Synonyms Cardiotrophin-1 Antibody, mAb, Mouse; Cardiophin 1 antibody

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