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Calreticulin Antibody, pAb, Rabbit

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Calreticulin is a multifunctional protein that serves as a major Ca2+-binding protein in the lumen of the endoplasmic reticulum. It binds to the synthetic peptide KLGFFKR, which is almost identical to an amino acid sequence in the DNA-binding domain of nuclear receptors. The amino terminus of calreticulin interacts with the DNA-binding domain of the glucocorticoid receptor and prevents the receptor from binding to its specific glucocorticoid response element. Calreticulin also serves as a recognition and clearance ligand by activating the internalization receptor LRP1 on the responding phagocyte cell surface.GenScript Rabbit Anti-Calreticulin Polyclonal Antibody is developed in rabbit using a KLH-coupled synthetic peptide from C-terminal of human Calreticulin (Swiss Prot: P27797).
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Specificity GenScript Rabbit Anti-Calreticulin Polyclonal Antibody detects endogenous levels of human Calreticulin. It is predicted to react with mouse and rat Calreticulin according to sequence homology.
Positive Control: Hela and HepG2
Host Species Rabbit
Immunogen KLH-coupled synthetic peptide from C-terminal of human Calreticulin (Swiss Prot: P27797).
Species Reactivity Human. This product has not been tested for other species yet.

Concentration 0.5 mg/ml, lyophilized with PBS, pH 7.4, containing 0.02% sodium azide
Reconstitution Reconstitute the lyophilized powder with deionized water (or equivalent) to an antibody concentration of 0.5 mg/ml.
Purification Immunoaffinity chromatography.

Target Background Calreticulin is a multifunctional protein that serves as a major Ca2+-binding protein in the lumen of the endoplasmic reticulum. It binds to the synthetic peptide KLGFFKR, which is almost identical to an amino acid sequence in the DNA-binding domain of nuclear receptors. The amino terminus of calreticulin interacts with the DNA-binding domain of the glucocorticoid receptor and prevents the receptor from binding to its specific glucocorticoid response element. Calreticulin also serves as a recognition and clearance ligand by activating the internalization receptor LRP1 on the responding phagocyte cell surface.
GenScript Rabbit Anti-Calreticulin Polyclonal Antibody is developed in rabbit using a KLH-coupled synthetic peptide from C-terminal of human Calreticulin (Swiss Prot: P27797).
Synonyms Rabbit Anti-CALR antibody;

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