PGP9.5 Antibody, pAb, Rabbit

PGP9.5 (also known as UCHL1) is primary neuronal specific member of the ubiquitin C-terminal hydrolase (UCH) family of DUBs. PGP9.5 is highly abundant in brain and constitute up to 2% of total protein. Normally, PGP9.5 is expressed exclusively in neurons and testis and is involved in several neurodegenerative diseases and cancers. Specially, PGP9.5 is associated with Parkinson disease (PD) and Alzheimer disease (AD). Overexpression of PGP9.5 protein occurs in many cancers, including lung and colorectal carcinoma. PGP9.5 is involved in regulating ubiquitin homeostasis, apoptosis, and learning and memory. It may play an important functional role in the biology of the mammalian central nervous system (CNS).GenScript Rabbit Anti-PGP9.5 Polyclonal Antibody is developed in rabbit using a KLH-coupled synthetic peptide from within residues 150-200 of human PGP9.5 (Swiss Prot: P09936).